Effects of chondroitin sulfate B on the reconstitution of collagen fibrils

Effects of chondroitin sulfate B on the reconstitution of collagen fibrils

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Collagen fibrils were reconstituted in vitro from type I collagen solution.The reconstituted collagen fibrils and chondroitin sulfate B were deposited 1073spx alternately.The adsorbed weight of the collagen fibrils and chondroitin sulfate B was measured using a quartz crystal microbalance (QCM) and their microstructure was observed using an atomic force microscope (AFM).The adsorbed weight of the collagen fibrils on the adsorption of collagen fibrils and chondroitin sulfate B alternately was significantly larger than that on the adsorption of collagen fibrils only.

The adsorption of chondroitin sulfate B was observed on the surfaces of collagen fibrils.These results indicate that chondroitin sulfate B is effective on the reconstitution hand wipes individual packets of collagen fibrils.